엔테카비어의 5년 치료 성적이 나왔군요 보세요
2010.01.11 16:22
Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B; Chang TT, Lai CL, Kew Yoon S, Lee SS, Coelho HS, Carrilho FJ, Poordad F, Halota W, Horsmans Y, Tsai N, Zhang H, Tenney DJ, Tamez R, Iloeje U; Hepatology (Jan 2010)
Sustained virologic suppression is a primary goal of therapy for chronic hepatitis B (CHB). In study entecavir (ETV)-022, 48 weeks of entecavir 0.5 mg was superior to lamivudine for virologic suppression for hepatitis B e antigen (HBeAg)-positive CHB. A total of 183 entecavir-treated patients from ETV-022 subsequently enrolled in study ETV-901. We present the results after up to 5 years (240 weeks) of continuous entecavir therapy. The entecavir long-term cohort consists of patients who received≥1 year of entecavir 0.5 mg in ETV-022 and then entered ETV-901 with a treatment gap≤35 days. In ETV-901 the entecavir dose was 1.0 mg daily. For patients with samples available at Year 5, proportions with hepatitis B virus (HBV) DNA<300 copies/mL, normal alanine aminotransferase (ALT) levels, HBeAg loss, and HBeAg seroconversion were determined. In all, 146 patients met criteria for inclusion in the entecavir long-term cohort. At Year 5, 94% (88/94) had HBV DNA<300 copies/mL and 80% (78/98) had normal ALT levels. In addition to patients who achieved serologic responses during study ETV-022, 23% (33/141) achieved HBeAg seroconversion and 1.4% (2/145) lost hepatitis B surface antigen (HBsAg) during study ETV-901. Through 5 years, entecavir resistance emerged in one patient. The safety profile of entecavir was consistent with previous reports. Conclusion: Extended therapy with entecavir through 5 years maintained or increased rates of HBV DNA suppression and ALT normalization. Additional patients also achieved HBeAg loss and seroconversion. Entecavir provides sustained viral suppression with minimal resistance during long-term treatment of HBeAg-positive CHB. (HEPATOLOGY 2010.)
댓글 5
-
윤구현
2010.01.11 19:44
오렌지색으로 강조하신 것만 보면...
5년간 썼을 때 HBV DNA 음성(300cpies/mL 이하)는 98%
ALT(간수치) 정상은 80%
e항원 혈청전환은 23%
s항원 음전은 1.4%
오늘 나온 기사를 보면 내성률은 5년에 1.2%라고 합니다.
양전호 선생님 좋은 내용 감사합니다....
늘 그렇듯 영어는 저에게도 이해하는 시간을 몇 배 늘리는 단점이.... ^^*
추천:1 댓글
-
Steven
2010.04.07 07:55
23%....
-
윤구현
2010.04.07 13:43
e항원 혈청전환율은 아래 표에서 볼 수 있듯이...
약들마다 거의 차이가 없습니다...
-
러브러쉬
2011.02.16 20:40
잘 읽었습니다.
불상한 시민들에게는 한글로 풀이를 해줘야...ㅠㅠ ㅎㅎㅎ